12/10 pubmed: adipose stem cell

Please add updates@feedmyinbox.com to your address book to make sure you receive these messages in the future. pubmed: adipose stem cell Tissue engineering with adipose-derived stem cells (ADSCs): current and future applications. December 9, 2009 at 7:18 am Related Articles Tissue engineering with adipose-derived stem cells (ADSCs): current and future applications. J Plast Reconstr Aesthet Surg. 2009 Dec 6; Authors: Sterodimas A, de Faria J, Nicaretta B, Pitanguy I Soft-tissue loss presents an ongoing challenge in plastic and reconstructive surgery. Standard approaches to soft-tissue reconstruction include autologous tissue flaps, autologous fat transplantation and alloplastic implants. All of these approaches have disadvantages, including donor-site morbidity, implant migration and absorption and foreign body reaction. Stem cell application has recently been suggested as a possible novel therapy. Adipose-derived stem cells (ADSCs) are an abundant, readily available population of multipotent progenitor cells that reside in adipose tissue, which is an easily accessible and abundant source of putative stem cells for translational clinical research. Their therapeutic use in pre-clinical studies and experimental clinical trials has been well documented. We present the current strategies of tissue engineering with ADSC and we discuss the possible future applications of this new method in the field of plastic and reconstructive surgery. Complete understanding of the mechanisms of interactions among adipose stem cells, growth factors and biomaterials in tissue engineering is still lacking. Adipose tissue stem cell-based regenerative strategies hold tremendous promise, although this potential must be balanced against stringent standards of scientific and clinical investigation, before developing 'off-the-shelf' tissue engineering products. PMID: 19969517 [PubMed - as supplied by publisher] Myoblasts Differentiated From Adipose-derived Stem Cells to Treat Stress Urinary Incontinence. December 9, 2009 at 7:18 am Related Articles Myoblasts Differentiated From Adipose-derived Stem Cells to Treat Stress Urinary Incontinence. Urology. 2009 Dec 5; Authors: Fu Q, Song XF, Liao GL, Deng CL, Cui L OBJECTIVES: To investigate the application of adipose-derived stem cell (ADSC) technology in the treatment of stress incontinence. METHODS: The vaginal balloon dilatation method was used to establish an animal model of stress incontinence (in 20 female Sprague-Dawley rats), which was further examined by urodynamics and histology. Endogenous rat ADSCs were collected and induced into myoblasts with 5-Aza induction technology in vitro. The identity of myoblasts was confirmed through immunofluorescence labeling with desmin and myosin. Induced cells were injected into the posterior urethral muscularis in the bladder neck of animals with stress incontinence. The effects were examined after 1 and 3 months by urodynamics and histology. Untreated ADSCs were also implanted as a method of control. RESULTS: Both maximal bladder capacity and leak point pressure significantly increased after 1 and 3 months postimplantation, compared with the control (P <.05). Increased thickness of inferior muscularis in urethral mucosa and a greater number of large longitudinal muscle bundles were observed. Increased numbers of myoblasts appeared under the mucosa, as demonstrated by the immunochemistry analysis of alpha-smooth actin. CONCLUSIONS: ADSCs have the ability of differentiating into multiple lineages, including myoblasts. This ability to induce myoblasts can be used to treat stress incontinence, with the advantages of minimal invasion and faster recovery. PMID: 19969332 [PubMed - as supplied by publisher]   This email was sent to agupta1213+termsc@gmail.com.  Manage Your Account Don't want to receive this feed any longer? Unsubscribe here.