| | | | | | | RegenMD | | | | | | | | | | | | | | | | On Tuesday, the med center announced creation of the Nebraska Regenerative Medicine Project and named UNMC stem cell researcher Nora Sarvetnick as its ... See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | ... stem cell transplantation, achieving better understanding of stem cell diseases such as leukemia and myeloma, and promoting regenerative medicine. ... See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | The project, announced Tuesday, will involve embryonic stem cells, adult stem cells and other forms of regenerative medicine. ... See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | "This partnership represents an important milestone as we continue Kensey Nash's mission as a developer of innovative regenerative medicine products," ... See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | ... under stress is crucial for understanding their response to metabolic stress and wound healing as well as their role and use in regenerative medicine. ... See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | With more troops surviving devastating injuries, the military is fast-tracking efforts in regenerative medicine, investigating risky measures to prevent ... See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | Branched vascular network architecture: a new approach to lung assist device technology. J Thorac Cardiovasc Surg. 2010 Nov;140(5):990-5 Authors: Hoganson DM, Anderson JL, Weinberg EF, Swart EJ, Orrick BK, Borenstein JT, Vacanti JP OBJECTIVE: A lung assist device would serve an important clinical need as a bridge to transplant or destination therapy for patients with end-stage lung disease. A new lung assist device has been developed that incorporates a branched network of vascular channels adjacent to a gas chamber, separated by a thin, gas-permeable membrane. This study investigated 2 potential gas exchange membranes within this new architecture. METHODS: Oxygen and carbon dioxide exchange within the device was tested in vitro using 3 gas-permeable membranes. Two of the membranes, silicone only and silicone-coated microporous polymer, were plasma impermeable. The third, a microporous polymer, was used as a control. Gas exchange testing was done using anticoagulated porcine blood over a range of flow rates. RESULTS: Oxygen and carbon dioxide transfer was demonstrated in the device and increased nearly linearly from 0.6 to 8.0 mL/min blood flow for all of the membranes. There was no significant difference in the gas transfer between the silicone and the silicone-coated microporous polymer membranes. The transfer of oxygen and carbon dioxide in the device was similar to existing hollow fiber oxygenators controlling for surface area. CONCLUSIONS: The silicone and silicone-coated microporous polymer membranes both show promise as gas-permeable membranes in a new lung assist device design. Further optimization of the device by improving the membranes and reducing the channel diameter in the vascular network will improve gas transfer. The current device may be scaled up to function as an adult lung assist device. PMID: 20591445 [PubMed - indexed for MEDLINE] | | | | | | | | | | | | | | | | | | | | | ... be used for human transplantation, researchers at the Wake Forest Institute for Regenerative Medicine have surpassed an early, but integral hurdle. ... See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | Regenerative medicine company, Mesoblast Limited, has announced that its US associate company, Angioblast Systems, has secured $1.2 million in grants under ... See all stories on this topic » | | | | | | | | | | | | | |
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