RegenMD - Pfizer's Neusentis Partners with Cellzome on Stem Cell Epigenetics Research

RegenMD         Pfizer's Neusentis Partners with Cellzome on Stem Cell Epigenetics Research May 10, 2011 at 8:32 AM   The research will combine Pfizer's expertise in stem cell handling and regenerative medicine, with Cellzome's Episphere™ platform. The Neusentis unit incorporates Pfizer's pre-existing regenerative medicines operation. Cellzome's bead-based Episphere ... See all stories on this topic »         3-D printers may someday allow labs to create replacment human organs May 10, 2011 at 8:32 AM   Tony Atala, director of the Wake Forest Institute for Regenerative Medicine in North Carolina, envisions what he calls "the Dell computer model," where a surgeon could order up "this hard drive, with this much memory …," only he or she would be ... See all stories on this topic »         In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors. May 10, 2011 at 8:20 AM   In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors. Blood. 2011 Mar 3;117(9):2618-24 Authors: Richie Ehrlich LI, Serwold T, Weissman IL The identity of T-cell progenitors that seed the thymus has remained controversial, largely because many studies differ over whether these progenitors retain myeloid potential. Contradictory reports diverge in their use of various in vitro and in vivo assays. To consolidate these discordant findings, we compared the myeloid potential of 2 putative thymus seeding populations, common lymphoid progenitors (CLPs) and multipotent progenitors (MPPs), and the earliest intrathymic progenitor (DN1), using 2 in vitro assays and in vivo readouts. These assays gave contradictory results: CLP and DN1 displayed surprisingly robust myeloid potential on OP9-DL1 in vitro stromal cocultures but displayed little myeloid potential in vivo, as well as in methylcellulose cultures. MPP, on the other hand, displayed robust myeloid potential in all settings. We conclude that stromal cocultures reveal cryptic, but nonphysiologic, myeloid potentials of lymphoid progenitors, providing an explanation for contradictory findings in the field and underscoring the importance of using in vivo assays for the determination of physiologic lineage potentials. PMID: 21163922 [PubMed - indexed for MEDLINE]         Project_aims_to_shed_light_on_the_epigenetic_mechanisms_ May 10, 2011 at 6:34 AM   Cellzome has announced a joint project with Pfizer's Pain & Sensory Disorders and Regenerative Medicine unit 'Neusentis', to characterise epigenetic factors involved in stem cell differentiation using Cellzome's Episphere technology. ... See all stories on this topic »             This email was sent to agupta1213+termsc@gmail.com. Delivered by Feed My Inbox PO Box 682532 Franklin, TN 37068 Account Login Unsubscribe Here