5/8 pubmed: adipose stem cell

Please add updates@feedmyinbox.com to your address book to make sure you receive these messages in the future. pubmed: adipose stem cell Mesenchymal stem cell therapy for cutaneous radiation syndrome. May 7, 2010 at 6:41 AM Mesenchymal stem cell therapy for cutaneous radiation syndrome. Health Phys. 2010 Jun;98(6):858-62 Authors: Akita S, Akino K, Hirano A, Ohtsuru A, Yamashita S Systemic and local radiation injuries caused by nuclear power reactor accidents, therapeutic irradiation, or nuclear terrorism should be prevented or properly treated in order to improve wound management and save lives. Currently, regenerative surgical modalities should be attempted with temporal artificial dermis impregnated and sprayed with a local angiogenic factor such as basic fibroblast growth factor, and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Human mesenchymal stem cells and adipose-derived stem cells, together with angiogenic and mitogenic factor of basic fibroblast growth factor and an artificial dermis, were applied over the excised irradiated skin defect and were tested for differentiation and local stimulation effects in the radiation-exposed wounds. The perforator flap and artificial dermal template with growth factor were successful for reconstruction in patients who were suffering from complex und! erlying disease. Patients were uneventfully treated with minimal morbidities. In the experiments, the hMSCs are strongly proliferative even after 20 Gy irradiation in vitro. In vivo, 4 Gy rat whole body irradiation demonstrated that sustained marrow stromal (mesenchymal stem) cells survived in the bone marrow. Immediate artificial dermis application impregnated with cells and the cytokine over the 20 Gy irradiated skin and soft tissues demonstrated the significantly improved fat angiogenesis, architected dermal reconstitution, and less inflammatory epidermal recovery. Detailed understanding of underlying diseases and rational reconstructive procedures brings about good outcomes for difficult irradiated wound healing. Adipose-derived stem cells are also implicated in the limited local injuries for short cell harvesting and processing time in the same subject. PMID: 20445394 [PubMed - in process]   Adipocyte Transplantation and Stem Cells: Plastic Surgery Meets Regenerative Medicine. May 7, 2010 at 6:41 AM Adipocyte Transplantation and Stem Cells: Plastic Surgery Meets Regenerative Medicine. Cell Transplant. 2010 May 4; Authors: Tremolada C, Palmieri G, Ricordi C The technologies for adipose tissue harvesting, processing and transplantation have substantially evolved in the past two decades. Clinically driven advancements have paralleled a significant improvement in the understanding of cellular, molecular and immunobiological events surrounding cell and tissue transplantation. These new mechanistic insights could be of assistance to better understand the mechanisms underlying some of the observed clinical improvements. In addition to plastic and reconstructive surgical applications, adipose tissue has become central to an increasing number of translational efforts involving adipose tissue derived progenitor cells. The growing interest in this area of research has brought to the exploration of many novel research and clinical applications that utilize adipose tissue grafting and/or progenitor/stem cell derived cell products obtained from this tissue source. Progenitor, endothelial and mesenchymal stem cells derived from ad! ipose tissue could therefore not only be central to plastic and reconstructive surgery applications, but also become the focus of an array of therapeutic solutions for many disease conditions, such as those affecting bone, cartilage, muscle, liver, kidney, cardiac, neural and the pancreas, expanding the possible indications and translational potential of tissue, cell based and regenerative medicine strategies. PMID: 20444320 [PubMed - as supplied by publisher]   Stem cells in the treatment of heart disease. May 7, 2010 at 6:41 AM Related Articles Stem cells in the treatment of heart disease. Annu Rev Med. 2010;61:287-300 Authors: Janssens S Progenitor cells residing in bone marrow, adipose tissue, and skeletal muscle or circulating in the blood are capable of improving myocardial function in preclinical models. In contrast, early clinical studies using bone marrow cells have shown mixed results and reflect our incomplete understanding of underlying mechanisms. Recent identification of various cardiac precursor cells has suggested an endogenous reservoir for cell-based repair. However, confronted with massive cardiac cell loss, inventive strategies and enabling technologies are required to mobilize or deliver functionally competent progenitor cells to sites of injury or to effectively stimulate endogenous repair. We review our present knowledge in this promising and rapidly evolving development in cardiovascular medicine and highlight obstacles as well as opportunities. PMID: 20059339 [PubMed - indexed for MEDLINE]   This email was sent to agupta1213+termsc@gmail.com.  Account Login Don't want to receive this feed any longer? Unsubscribe here This email was carefully delivered by Feed My Inbox. 230 Franklin Road Suite 814 Franklin, TN 37064