|  |  |  | | | | | RegenMD | | | | | | | | | | | | | | | | | | The Center for Regenerative Medicine in Miami Beach, Florida, concentrates on helping arthritic and injured people to get back to a functional level of life and their activities using non-surgical techniques and orthopedic medicine. ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | Using a technology he invented, Brown researcher William Fairbrother and colleagues have discovered new molecular interactions in the process that will help regenerative medicine researchers better understand pluripotency. ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | The 21st annual Australasian Society for Biomaterials and Tissue Engineering Conference kicked off yesterday and has attracted top international speakers, some of them leading researchers and lecturers. Keynote speaker University of Washington ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | ... normal human primary mesenchymal stem cells derived from human umbilical cord matrices (Wharton's Jelly) — invaluable tools used for research studies that include developmental biology, regenerative medicine, cell therapy, and tissue engineering. ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | ... normal human primary mesenchymal stem cells derived from human umbilical cord matrices (Wharton's Jelly) — invaluable tools used for research studies that include developmental biology, regenerative medicine, cell therapy, and tissue engineering. ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | IntelliCell BioSciences Inc. is an emerging leader in regenerative medicine using adipose (fat) derived stromal vascular fraction containing adult stem cells. The company has developed proprietary technologies that allow for the efficient and ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | Angioscaff is developing radical new scaffolds, biomaterials and tissue engineering strategies for the regeneration of bone, skin, skeletal muscle, the cardiovascular, peripheral vascular and central nervous systems. Now at its halfway point, ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | We are also hopeful that the counsel of this working group will prove useful to others who endeavor to realize the potential of dental stem cells for regenerative medicine and dentistry." In 2000, researchers at the US National Institutes of Health ...
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PR Web (press release) |
| | | | | | | | | | | | | | | | | | | | | | | | However, there is one FDA approval related story that is a bit more unusual and involves a company with a medical technology that could represent a new paradigm in regenerative medicine. Has anyone ever heard of a situation where a company tied the ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | | Mitochondrial biogenesis drives tumor cell proliferation. Am J Pathol. 2011 May;178(5):1949-52 Authors: Martinez-Outschoorn UE, Pavlides S, Sotgia F, Lisanti MP PMID: 21514412 [PubMed - in process] | | | | | | | | | | | | | | | | | | | | | | | | | Adipose tissue-derived stem cell in vitro differentiation in a three-dimensional dental bud structure. Am J Pathol. 2011 May;178(5):2299-310 Authors: Ferro F, Spelat R, Falini G, Gallelli A, D'Aurizio F, Puppato E, Pandolfi M, Beltrami AP, Cesselli D, Beltrami CA, Ambesi-Impiombato FS, Curcio F Tooth morphogenesis requires sequential and reciprocal interactions between the cranial neural crest-derived mesenchymal cells and the stomadial epithelium, which regulate tooth morphogenesis and differentiation. We show how mesenchyme-derived single stem cell populations can be induced to transdifferentiate in vitro in a structure similar to a dental bud. The presence of stem cells in the adipose tissue has been previously reported. We incubated primary cultures of human adipose tissue-derived stem cells in a dental-inducing medium and cultured the aggregates in three-dimensional conditions. Four weeks later, cells formed a three-dimensional organized structure similar to a dental bud. Expression of dental tissue-related markers was tested assaying lineage-specific mRNA and proteins by RT-PCR, immunoblot, IHC, and physical-chemical analysis. In the induction medium, cells were positive for ameloblastic and odontoblastic markers as both mRNAs and proteins. Also, cells expressed epithelial, mesenchymal, and basement membrane markers with a positional relationship similar to the physiologic dental morphogenesis. Physical-chemical analysis revealed 200-nm and 50-nm oriented hydroxyapatite crystals as displayed in vivo by enamel and dentin, respectively. In conclusion, we show that adipose tissue-derived stem cells in vitro can transdifferentiate to produce a specific three-dimensional organization and phenotype resembling a dental bud even in the absence of structural matrix or scaffold to guide the developmental process. PMID: 21514442 [PubMed - in process] | | | | | | | | | |  | |  | |  |
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