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RegenMD         Discovery brings embryonic stem cells closer to mainstream medicine February 4, 2011 at 9:43 PM   ... and then maintaining those stem cells without large-scale cell die-off, has been a major roadblock in the area of regenerative medicine. ... See all stories on this topic »         Spray-on stem cells aid burn victims February 4, 2011 at 1:38 PM   Dr. Jorg Gerlach of the McGowan Institute for Regenerative Medicine at the University of Pittsburgh developed the technique, which makes a second-degree ... See all stories on this topic » CBC.ca         TSB to manage regenerative-medicine funding competitions February 4, 2011 at 11:58 AM   The Technology Strategy Board (TSB) is to manage two funding competitions as part of the £21.5m Regenerative Medicine Programme. ... See all stories on this topic »         COLUMN: Stem cell science links us to world February 4, 2011 at 10:41 AM   ... in adult stem cell research could be a bridge to a future of regenerative medicine that does not depend upon the destruction of human embryos. ... See all stories on this topic »         Stem cell leader awarded $2.3 million grant for Parkinson's February 4, 2011 at 10:41 AM   LA JOLLA, CA-The Salk Institute has been awarded a $2.3 million grant by the California Institute for Regenerative Medicine (CIRM) for translational ... See all stories on this topic »         Direct comparison of progenitor cells derived from adipose, muscle, and bone marrow from wild-type or craniosynostotic rabbits. February 4, 2011 at 9:28 AM   Direct comparison of progenitor cells derived from adipose, muscle, and bone marrow from wild-type or craniosynostotic rabbits. Plast Reconstr Surg. 2011 Jan;127(1):88-97 Authors: Cooper GM, Durham EL, Cray JJ, Bykowski MR, DeCesare GE, Smalley MA, Mooney MP, Campbell PG, Losee JE Reports have identified cells capable of osteogenic differentiation in bone marrow, muscle, and adipose tissues, but there are few direct comparisons of these different cell types. Also, few have investigated the potential connection between a tissue-specific abnormality and cells derived from seemingly unrelated tissues. In this article, the authors compare cells isolated from wild-type rabbits or rabbits with nonsyndromic craniosynostosis, defined as the premature fusion of one or more of the cranial sutures. PMID: 20871482 [PubMed - indexed for MEDLINE]         Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. February 4, 2011 at 9:28 AM   Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. J Clin Invest. 2011 Jan 4;121(1):446-53 Authors: Bailey CG, Ryan RM, Thoeng AD, Ng C, King K, Vanslambrouck JM, Auray-Blais C, Vandenberg RJ, Bröer S, Rasko JE Solute carrier family 1, member 1 (SLC1A1; also known as EAAT3 and EAAC1) is the major epithelial transporter of glutamate and aspartate in the kidneys and intestines of rodents. Within the brain, SLC1A1 serves as the predominant neuronal glutamate transporter and buffers the synaptic release of the excitatory neurotransmitter glutamate within the interneuronal synaptic cleft. Recent studies have also revealed that polymorphisms in SLC1A1 are associated with obsessive-compulsive disorder (OCD) in early-onset patient cohorts. Here we report that SLC1A1 mutations leading to substitution of arginine to tryptophan at position 445 (R445W) and deletion of isoleucine at position 395 (I395del) cause human dicarboxylic aminoaciduria, an autosomal recessive disorder of urinary glutamate and aspartate transport that can be associated with mental retardation. These mutations of conserved residues impeded or abrogated glutamate and cysteine transport by SLC1A1 and led to near-absent surface expression in a canine kidney cell line. These findings provide evidence that SLC1A1 is the major renal transporter of glutamate and aspartate in humans and implicate SLC1A1 in the pathogenesis of some neurological disorders. PMID: 21123949 [PubMed - indexed for MEDLINE]         'Spray-on skin' developed for burns victims February 4, 2011 at 4:52 AM   The process takes only 90 minutes, said Dr Jörg Gerlach, of the University of Pittsburgh's McGowan Institute for Regenerative Medicine. ... See all stories on this topic » Telegraph.co.uk             This email was sent to regenmd@gmail.com. Delivered by Feed My Inbox PO Box 682532 Franklin, TN 37068 Account Login Unsubscribe Here