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RegenMD         Paul Sanberg receives Everfront Award at stem cell conference in Taiwan April 29, 2011 at 4:34 PM   In particular, Dr. Sanberg's pioneering efforts in regenerative medicine for neurodegenerative disorders, capture the award's core criteria, Dr. Lin said. Dr. Sanberg, a keynote speaker at the symposium, praised Taiwan and the China Medical University ... See all stories on this topic »         Faculty Senate approves stem cell doctoral program April 29, 2011 at 6:37 AM   The Faculty Senate approved a new interdisciplinary program in stem cell biology and regenerative medicine (SCBRM) in a unanimous voice vote on Thursday. The SCBRM program seeks a five-year trial period beginning Sept. 11, 2011 through Aug. 31, 2016. ... See all stories on this topic »         Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. April 29, 2011 at 4:01 AM   Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. J Clin Invest. 2011 Mar 1;121(3):1217-21 Authors: Narsinh KH, Sun N, Sanchez-Freire V, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Robbins RC, Wu JC Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) are promising candidate cell sources for regenerative medicine. However, despite the common ability of hiPSCs and hESCs to differentiate into all 3 germ layers, their functional equivalence at the single cell level remains to be demonstrated. Moreover, single cell heterogeneity amongst stem cell populations may underlie important cell fate decisions. Here, we used single cell analysis to resolve the gene expression profiles of 362 hiPSCs and hESCs for an array of 42 genes that characterize the pluripotent and differentiated states. Comparison between single hESCs and single hiPSCs revealed markedly more heterogeneity in gene expression levels in the hiPSCs, suggesting that hiPSCs occupy an alternate, less stable pluripotent state. hiPSCs also displayed slower growth kinetics and impaired directed differentiation as compared with hESCs. Our results suggest that caution should be exercised before assuming that hiPSCs occupy a pluripotent state equivalent to that of hESCs, particularly when producing differentiated cells for regenerative medicine aims. PMID: 21317531 [PubMed - indexed for MEDLINE]         Tiny robots self-assemble with a single command - robots use electrostatic power April 29, 2011 at 3:05 AM   "We're trying to come up with ways of self-assembling little tissue units," says Ali Khademhosseini, an associate professor at Brigham and Women's Hospital at Harvard Medical School and a specialist in tissue engineering who is collaborating with ... See all stories on this topic » Next Big Future             This email was sent to regenmd@gmail.com. Delivered by Feed My Inbox PO Box 682532 Franklin, TN 37068 Account Login Unsubscribe Here