9/13 pubmed: adipose stem cell

Please add updates@feedmyinbox.com to your address book to make sure you receive these messages in the future. pubmed: adipose stem cell Cross-talk between BubR1 expression and commitment to differentiate in adipose-derived mesenchymal stem cells. September 12, 2009 at 6:58 am Cross-talk between BubR1 expression and commitment to differentiate in adipose-derived mesenchymal stem cells. Exp Mol Med. 2009 Sep 11; Authors: Lee J, Lee CG, Lee KW, Lee CW The BubR1 mitotic checkpoint kinase monitors attachment of microtubules to kinetochores and links regulation of chromosome-spindle attachment to mitotic checkpoint signaling. Defects in BubR1-mediated signaling severely perturb checkpoint control and are linked to diseases such as cancer. Studies with BubR1 mouse models suggest that BubR1 activities prevent premature aging and infertility. In this study, we show that BubR1 depletion in human adipose-derived mesenchymal stem cells (ASCs) precedes the loss of differentiation potential and the induction of replicative senescence. These effects occur independently of p16(INK4A) expression and may involve DNA methylation. Our data therefore reveal a new and unsuspected feature of BubR1 expression in the regulation of adult stem cell differentiation. PMID: 19745606 [PubMed - as supplied by publisher]   This email was sent to agupta1213+termsc@gmail.com.  Manage Your Account Don't want to receive this feed any longer? Unsubscribe here.