9/5 pubmed: adipose stem cell

Please add updates@feedmyinbox.com to your address book to make sure you receive these messages in the future. pubmed: adipose stem cell Androgen mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF-1, MGF and induction of beta-catenin. September 4, 2009 at 7:26 am Related Articles Androgen mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF-1, MGF and induction of beta-catenin. J Mol Endocrinol. 2009 Sep 2; Authors: Gentile MA, Nantermet PV, Vogel RL, Phillips R, Holder D, Hodor P, Dai H, Cheng C, Freedman LP, Ray WJ Androgens promote anabolism in the musculoskeletal system while repressing adiposity, leading to favorable body composition. Circulating androgens decline with age, contributing to frailty, osteoporosis, and obesity, however the mechanisms by which androgens promote favorable body composition are largely unknown. Here we demonstrate that aged castrated rats develop increased fat mass, reduced muscle mass and strength, and lower bone mass. Treatment with testosterone (T) or 5a-dihydrotestosterone (DHT) reverses the effects on muscle and adipose tissues while only aromatizable T increased bone mass. During the first week, DHT transiently increased soleus muscle nuclear density and induced expression of insulin-like growth factor-1 (IGF-1) and its splice variant mechano growth factor (MGF) without early regulation of the myogenic factors MyoD, myogenin, MNF, or myostatin. Thus a genome-wide microarray screen was performed to identify potential pro-myogenic genes that respond to androgen receptor activation in vivo within 24 hours. Of 24,000 genes examined, 70 candidate genes were identified whose functions suggest initiation of remodeling and regeneration, including the type II muscle genes for myosin heavy chain II and parvalbumin and the chemokine MCP-1. Interestingly, Axin and Axin2, negative regulators of Beta-catenin, were repressed, indicating modulation of the Beta-catenin. DHT increased total levels of Beta-catenin protein, which accumulated in nuclei in vivo. Likewise, treatment of C2C12 myoblasts with both IGF-1Ea and MGF c-terminal peptide increased nuclear Beta-catenin in vitro. Thus we propose that androgenic anabolism involves downregulation of axin, and induction of IGF-1, leading to nuclear accumulation of Beta-catenin, a pro-myogenic, anti-adipogenic stem cell regulatory factor. PMID: 19726620 [PubMed - as supplied by publisher] [Regenerative medicine for anti-aging] September 4, 2009 at 7:26 am Related Articles [Regenerative medicine for anti-aging] Nippon Rinsho. 2009 Jul;67(7):1402-6 Authors: Ebisawa K, Kagami H, Kato R, Yamada Y, Ueda M Regenerative medicine refers to research and treatments that restore damaged tissues. It consists of three factors: cells, chemical substances, and scaffolds. One of its purposes is rejuvenation, and from this point of view, it really resembles anti-aging medicine. Recently, studies concerning stem cells such as embryonic stem cells (ES) and induce pluripotent stem cells (iPS) have made remarkable progress and seem promising, but are still far from clinical use. In contrast, we introduce a few examples of anti-aging medicine using regenerative medicine methods that have been applied successfully in clinical use such as cultured fibroblast, adipose tissue derived stem cells and platelet rich plasma (PRP), and continue researching cultured dermal papilla cells. PMID: 19591293 [PubMed - indexed for MEDLINE]   This email was sent to agupta1213+termsc@gmail.com.  Manage Your Account Don't want to receive this feed any longer? Unsubscribe here.