Tuesday, October 6, 2009

10/7 pubmed: adipose stem cell

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Stem cells for stress urinary incontinence: the adipose promise.
October 6, 2009 at 6:43 am

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Stem cells for stress urinary incontinence: the adipose promise.

J Cell Mol Med. 2009 Oct 3;

Authors: Roche R, Festy F, Fritel X

Abstract Stress urinary incontinence (SUI), the most common type of incontinence in women, is a frequent and costly ailment responsible for an alteration to the quality of life. While medical treatment give some rather deceiving results, surgical techniques that include colposuspension or tension-free vaginal tape, employed in cases of urethral support defect, give a 5 year cure rate of more than 80%. However, these techniques could lead to complications or recurrence of symptoms. Recently, the initiation of urethral cell therapy has been undertaken by doctors and researchers. One principal source of autologous adult stem cells is generally used: muscle precursor cells (MPCs) which are the progenitors of skeletal muscle cells. Recently, a few research groups have shown interest in the MPCs and their potential for the treatment of urinary incontinence. However, using MPCs or fibroblasts isolated from a striated muscle biopsy could be questionable on several point. One of them is the in vitro cultivation of cells, which raises issues over the potential cost of the technique. Besides, numerous studies have shown the multipotent or even the pluripotent nature of stromal vascular cells (SVF) or adipose-derived stem cells (ASCs) from adipose tissue. These cells are capable of acquiring in vitro many different phenotypes. Furthermore, recent animal studies have highlighted the potential interest of SVF cells or ASCs in cell therapy, in particular for mesodermal tissue repair and revascularization. Moreover, the potential interest of SVF cells or ASCs for the treatment of urinary incontinence in women is supported by many other characteristics of these cells that are discussed here. Since access to these cells via lipoaspiration is simple, and due to the fact that they are found in very large numbers in adipose tissue, their future potential as a stem cell reservoir for use urethral or other types of cell therapy is enormous.

PMID: 19799652 [PubMed - as supplied by publisher]

 

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