| Induction of tumoricidal activity in mouse peritoneal macrophages by ginseng polysaccharide. Int J Biol Macromol. 2010 Feb 12; Authors: Wang J, Zuo G, Li J, Guan T, Li C, Jiang R, Xie B, Lin X, Li F, Wang Y, Chen D This study examined the effects of ginseng polysaccharide (GPS) on mouse peritoneal macrophage(PM)-mediated cytotoxicity towards K562, HL-60, or KG1alpha cells. GPS had no direct effect on kil! ling of tumor cells. However, when mouse PMs were treated with GPS, cytotoxic activity against K562, HL-60, or KG1alpha cells was significantly induced. In addition, phagocytic activity was enhanced in GPS-treated mouse PMs compared to the control. The expressions of CD(68), ACP and alpha-ANE in mouse PMs were increased by the treatment with GPS. Moreover, the levels of cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), IL-6 were increased and the production of nitric oxide (NO) was enhanced. Taken together, these results suggest that GPS possess a potent anti-tumor activity by stimulating macrophage and a potentiality as an immunomodulator against diseases such as cancer. PMID: 20156477 [PubMed - as supplied by publisher] | 
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