Thursday, May 20, 2010

5/21 TE-RegenMed-StemCell feed

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New NIH Conflict Rules and Their Impact on CIRM
May 20, 2010 at 6:42 PM

The NIH today unveiled proposed new conflict-of-interest rules that will reach deep into stem cell research circles in California, touching the state's stem cell agency and affecting 40,000 scientists nationwide.

Francis Collins, director of the NIH, said the rules are aimed at preserving public trust in research ethics and the "integrity of the scientific enterprise."

According to a report
 

[Differentiation characteristics of human periodontal ligament cell population in vitro]
May 20, 2010 at 6:21 AM

[Differentiation characteristics of human periodontal ligament cell population in vitro]

Hua Xi Kou Qiang Yi Xue Za Zhi. 2010 Apr;28(2):185-9

Authors: Liu J, Zha HY, Xuan DY, Xie BY, Zhang JC

OBJECTIVE: To explore the multi-differentiated capability of human periodontal ligament cell population (hPDLP), and provide a theoretical basis for the periodontal regeneration by tissue engineering technique. METHODS: hPDLP was cultured from periodontium of human tooth by the outgrowth method. STRO-1 and CD 146 expression were investigated by flow cytometry. hPDLP was induced to odontogenic/osteogenic-like and adipogenic-like cell. The multilineage differentiation capacities of hPDLP were evaluated by alizarin red stain, oil red O stain, anti-CD146 and STRO-1 immunocytochemistry, and reverse-transcriptase polymerase chain reaction analysis. RESULTS: hPDLP was isolated from human periodontium and most of the cells retained their fibroblastic spindle shape. hPDLP can be induced into osteoblast-like cells and adipocyte-like cells, and calcium deposition and lipid droplets were detected perspectively. And the eighth generation of hPDLP had weaker potential into adip! ocyte-like cells than the first passage, however, there was no difference to the aspect of calcification ability between the two passages. CONCLUSION: hPDLP cultured in vitro can differentiate into adipocytes and osteoblasts, and the first to third passage cells may have the predominance of differentiation potential.

PMID: 20480665 [PubMed - in process]

 

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