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Please add updates@feedmyinbox.com to your address book to make sure you receive these messages in the future. RegenMD A new method for studying gradient-induced neutrophil desensitization based on an open microfluidic chamber. May 8, 2010 at 9:13 AM Related Articles A new method for studying gradient-induced neutrophil desensitization based on an open microfluidic chamber. Lab Chip. 2010 Jan 7;10(1):116-22 Authors: Keenan TM, Frevert CW, Wu A, Wong V, Folch A During inflammation neutrophils rapidly migrate to the site of tissue damage or infection by following complex gradients of bacterial peptides and host-derived chemokines. The efficiency and speed of neutrophil migration is critically dependent ! upon the ability of neutrophils to sense new gradients and utilize only those that provide the most direct path to the damaged or infected site. Receptor desensitization plays an important role in migration efficiency and is most commonly studied using bath application of chemotactic factor solutions instead of presenting cells with gradients analogous to those they would experience in vivo. Here we describe a new method for examining gradient-induced neutrophil desensitization using a previously-developed open-chamber microfluidic gradient generator. PMID: 20024059 [PubMed - indexed for MEDLINE]   This email was sent to regenmd@gmail.com.  Account Login Don't want to receive this feed any longer? Unsubscribe here This email was carefully delivered by Feed My Inbox. 230 Franklin Road Suite 814 Franklin, TN 37064