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RegenMD         Call for Papers: Expanding Human Boundaries: Cognitive Enhancement ... March 29, 2011 at 10:13 PM   One vector is cognitive enhancement using pharmaceuticals, genetic therapies and tissue engineering. Direct modification of the organic brain will allow ...         EMBARGOED FOR RELEASE: Tuesday, March 29, 4:50 pm, Eastern Time March 29, 2011 at 9:36 PM   ... King Saud University, Riyadh, Riyadh, Saudi Arabia, said that besides drug delivery, nanofibers are being used for tissue engineering, wound dressing, ...         Limited Spacing Left With One Week Left to Register for the 2011 Translational ... March 29, 2011 at 9:17 PM   WINSTON-SALEM, NC--(Marketwire - March 29, 2011) - The 2011 Translational Regenerative Medicine Forum, hosted by the Regenerative Medicine Foundation will commence next week on April 6 at the Ronald Reagan Building and International Trade Center in ... See all stories on this topic »         Investigators discover enzyme essential for healthy lung development March 29, 2011 at 9:17 PM   David Warburton, MD, director of Developmental Biology and Regenerative Medicine at The Saban Research Institute, and Ahmed El-Hashash, PhD, senior research scientist carrying out this study, will release their findings in the upcoming issue of ... See all stories on this topic »         Biotech: Healing One Cell at a Time March 29, 2011 at 2:03 PM   The Tissue Engineering Resource Center at Tufts University is funded by an NIH grant. Among other things, the center is working on scaffold designs to ...         Pathfinder Cells Demonstrate Ability to Regenerate Damaged Tissue and Restore ... March 29, 2011 at 10:05 AM   The further development of PCs as a vehicle for regenerative medicine offers exciting prospects for future therapies." Pathfinder is developing a novel cell-based therapy with the potential to revolutionize the treatment of diabetes, renal disease, ... See all stories on this topic »         Rescue of lethal hepatic failure by hepatized lymph nodes in mice. March 29, 2011 at 8:31 AM   Rescue of lethal hepatic failure by hepatized lymph nodes in mice. Gastroenterology. 2011 Feb;140(2):656-666.e2 Authors: Hoppo T, Komori J, Manohar R, Stolz DB, Lagasse E Hepatocyte transplantation is a potential therapeutic approach for liver disease. However, most patients with chronic hepatic damage have cirrhosis and fibrosis, which limit the potential for cell-based therapy of the liver. The development of an ectopic liver as an additional site of hepatic function represents a new approach for patients with end-stage liver disease. We investigated the development and function of liver tissue in lymph nodes in mice with liver failure. PMID: 21070777 [PubMed - indexed for MEDLINE]         Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. March 29, 2011 at 8:31 AM   Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. J Clin Invest. 2011 Feb 1;121(2):525-33 Authors: Rentschler S, Harris BS, Kuznekoff L, Jain R, Manderfield L, Lu MM, Morley GE, Patel VV, Epstein JA Ventricular preexcitation, which characterizes Wolff-Parkinson-White syndrome, is caused by the presence of accessory pathways that can rapidly conduct electrical impulses from atria to ventricles, without the intrinsic delay characteristic of the atrioventricular (AV) node. Preexcitation is associated with an increased risk of tachyarrhythmia, palpitations, syncope, and sudden death. Although the pathology and electrophysiology of preexcitation syndromes are well characterized, the developmental mechanisms are poorly understood, and few animal models that faithfully recapitulate the human disorder have been described. Here we show that activation of Notch signaling in the developing myocardium of mice can produce fully penetrant accessory pathways and ventricular preexcitation. Conversely, inhibition of Notch signaling in the developing myocardium resulted in a hypoplastic AV node, with specific loss of slow-conducting cells expressing connexin-30.2 (Cx30.2) and a resulting loss of physiologic AV conduction delay. Taken together, our results suggest that Notch regulates the functional maturation of AV canal embryonic myocardium during the development of the specialized conduction system. Our results also show that ventricular preexcitation can arise from inappropriate patterning of the AV canal-derived myocardium. PMID: 21266778 [PubMed - indexed for MEDLINE]             This email was sent to regenmd@gmail.com. Delivered by Feed My Inbox PO Box 682532 Franklin, TN 37068 Account Login Unsubscribe Here