|  |  |  | | | | | RegenMD | | | | | | | | | | | | | | | | | | Biomedical Structures LLC (BMS) — a Warwick, RI-based manufacturer of biomedical textiles for medical devices and other clinical applications including cardiovascular, orthopedic, general surgery and tissue engineering — has acquired Concordia ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | ... general surgery and tissue engineering — has acquired Concordia Medical LLC — a provider of medical implant technologies using biomaterials for tissue engineering and regenerative medicine, and a division of Warwick-based engineered fiber ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | Department of Urology and Institute of Regenerative Medicine, Robotics and Minimally Invasive Surgery, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1094, USA. Open partial nephrectomy for the treatment ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | As CEO of Cleveland-based regenerative medicine startups Juventas Therapeutics and SironRX Therapeutics, Rahul Aras is doing just that. Each company is developing therapies based off the same technology, a growth factor called JVS-100 that recruits ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | by Donna Miles 3/21/2011 - FORT DETRICK, Md. (AFNS) -- New hope is on the horizon for wounded warriors suffering debilitating burns as officials from the Armed Forces Institute of Regenerative Medicine and their partners at medical research centers ...
See all stories on this topic » | | | | | | | | | | | | | | | | | | | | | | | | | SDF-1:CXCR4 axis is fundamental for tissue preservation and repair. Am J Pathol. 2010 Nov;177(5):2166-8 Authors: Penn MS PMID: 20889567 [PubMed - indexed for MEDLINE] | | | | | | | | | | | | | | | | | | | | | | | | | Pharmacologic modulation of the calcium-sensing receptor enhances hematopoietic stem cell lodgment in the adult bone marrow. Blood. 2011 Jan 27;117(4):1167-75 Authors: Lam BS, Cunningham C, Adams GB The ability of hematopoietic stem cells (HSCs) to undergo self-renewal is partly regulated by external signals originating from the stem cell niche. Our previous studies with HSCs obtained from fetal liver of mice deficient for the calcium-sensing receptor (CaR) have shown the crucial role of this receptor in HSC lodgment and engraftment in the bone marrow (BM) endosteal niche. Using a CaR agonist, Cinacalcet, we assessed the effects of stimulating the CaR on the function of murine HSCs. Our results show that CaR stimulation increases primitive hematopoietic cell activity in vitro, including growth in stromal cell cocultures, adhesion to extracellular matrix molecules such as collagen I and fibronectin, and migration toward the chemotactic stimulus, stromal cell-derived factor 1α. Receptor stimulation also led to augmented in vivo homing, CXCR4-mediated lodgment at the endosteal niche, and engraftment capabilities. These mechanisms by which stimulating the CaR dictates preferential localization of HSCs in the BM endosteal niche provide additional insights into the fundamental interrelationship between the stem cell and its niche. These studies also have implications in the area of clinical stem cell transplantation, where ex vivo modulation of the CaR may be envisioned as a strategy to enhance HSC engraftment in the BM. PMID: 21076044 [PubMed - indexed for MEDLINE] | | | | | | | | | |  | |  | |  |
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