RegenMD - Mesoblast Limited (ASX:MSB) CEO Named BioSpectrum Asia Person Of The Year 2011

RegenMD         Mesoblast Limited (ASX:MSB) CEO Named BioSpectrum Asia Person Of The Year 2011 March 16, 2011 at 8:51 PM   "BioSpectrum has recognized Mesoblast's leadership in the global regenerative medicine industry, the tremendous promise of our proprietary adult stem cells to treat major diseases, and the company's ability to grow through valuable strategic alliances ... See all stories on this topic » ABN Newswire (press release)         ACT Interim Chairman and CEO Gary Rabin to Present at BIO-Europe Spring 2011 ... March 16, 2011 at 1:00 PM   Webcasting is not available but following the conference a copy of Mr. Advanced Cell Technology, Inc. is a biotechnology company applying cellular technology in the field of regenerative medicine. Statements in this news release regarding future ... See all stories on this topic »         Important funding for nanomedicine research to improve diagnosis and treatment March 16, 2011 at 1:00 PM   Toronto (March 16, 2011) – Seven new research projects on regenerative medicine and nanomedicine received $16 million in funding. The studies, co-funded by the Canadian Institutes of Health Research (CIHR) and the Canadian Space Agency (CSA), ... See all stories on this topic »         Regenerative medicine has gone to the dogs March 16, 2011 at 11:29 AM   Art Gentile/Staff Photographer Dr Przemyslaw Romiszewski, veterinarian at the Animal Medical Center in Buckingham along with vet technicians, Ellen O'Toole and Amy Turner, shave Max, an 11-yr-old Rottweiler, Lab mix before performing Bucks County's ... See all stories on this topic »         A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer. March 16, 2011 at 11:25 AM   A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer. Am J Pathol. 2010 Dec;177(6):3180-91 Authors: Llaverias G, Danilo C, Wang Y, Witkiewicz AK, Daumer K, Lisanti MP, Frank PG Epidemiological studies have provided evidence suggesting an important role for diet and obesity in the development of cancer. Specifically, lipid nutrients of the diet have been identified as important regulators of tumor development and progression. In the present study, we have examined the role of dietary fat and cholesterol in the initiation and progression of prostate cancer using the well-characterized TRAMP mouse model. Consumption of a Western-type diet--that is, enriched in both fat and cholesterol--accelerated prostate tumor incidence and tumor burden compared to mice fed a control chow diet. Furthermore, we also show that this diet increased the extent and the histological grade of prostate tumors. These findings were confirmed by the presence of increased levels of protein markers of advanced tumors in prostates obtained from animals fed a Western-type diet compared to those obtained from control animals. Increased lung metastases in animals fed a Western-type diet were also observed. In addition, we found that with a Western diet, animals bearing tumors presented with reduced plasma cholesterol levels compared with animals fed a control diet. Finally, we show that tumors obtained from animals fed a Western-type diet displayed increased expression of the high-density lipoprotein receptor SR-BI and increased angiogenesis. Taken together, our data suggest that dietary fat and cholesterol play an important role in the development of prostate cancer. PMID: 21088217 [PubMed - indexed for MEDLINE]         Development of a bioengineered skin-humanized mouse model for psoriasis: dissecting epidermal-lymphocyte interacting pathways. March 16, 2011 at 11:25 AM   Development of a bioengineered skin-humanized mouse model for psoriasis: dissecting epidermal-lymphocyte interacting pathways. Am J Pathol. 2010 Dec;177(6):3112-24 Authors: Guerrero-Aspizua S, García M, Murillas R, Retamosa L, Illera N, Duarte B, Holguín A, Puig S, Hernández MI, Meana A, Jorcano JL, Larcher F, Carretero M, Del Río M Over the past few years, whole skin xenotransplantation models that mimic different aspects of psoriasis have become available. However, these models are strongly constrained by the lack of skin donor availability and homogeneity. We present in this study a bioengineering-based skin-humanized mouse model for psoriasis, either in an autologous version using samples derived from psoriatic patients or, more importantly, in an allogeneic context, starting from skin biopsies and blood samples from unrelated healthy donors. After engraftment, the regenerated human skin presents the typical architecture of normal human skin but, in both cases, immunological reconstitution through intradermal injection in the regenerated skin using in vitro-differentiated T1 subpopulations as well as recombinant IL-17 and IL-22 Th17 cytokines, together with removal of the stratum corneum barrier by a mild abrasive treatment, leads to the rapid conversion of the skin into a bona fide psoriatic phenotype. Major hallmarks of psoriasis were confirmed by the evaluation of specific epidermal differentiation and proliferation markers as well as the mesenchymal milieu, including angiogenesis and infiltrate. Our bioengineered skin-based system represents a robust platform to reliably assess the molecular and cellular mechanisms underlying the complex interdependence between epidermal cells and the immune system. The system may also prove suitable to assess preclinical studies that test the efficacy of novel therapeutic treatments and to predict individual patient response to therapy. PMID: 20971736 [PubMed - indexed for MEDLINE]         The Emerging Role of Epigenetics in Stroke: III. Neural Stem Cell Biology and Regenerative Medicine. March 16, 2011 at 11:25 AM   The Emerging Role of Epigenetics in Stroke: III. Neural Stem Cell Biology and Regenerative Medicine. Arch Neurol. 2011 Mar;68(3):294-302 Authors: Qureshi IA, Mehler MF The transplantation of exogenous stem cells and the activation of endogenous neural stem and progenitor cells (NSPCs) are promising treatments for stroke. These cells can modulate intrinsic responses to ischemic injury and may even integrate directly into damaged neural networks. However, the neuroprotective and neural regenerative effects that can be mediated by these cells are limited and may even be deleterious. Epigenetic reprogramming represents a novel strategy for enhancing the intrinsic potential of the brain to protect and repair itself by modulating pathologic neural gene expression and promoting the recapitulation of seminal neural developmental processes. In fact, recent evidence suggests that emerging epigenetic mechanisms are critical for orchestrating nearly every aspect of neural development and homeostasis, including brain patterning, neural stem cell maintenance, neurogenesis and gliogenesis, neural subtype specification, and synaptic and neural network connectivity and plasticity. In this review, we survey the therapeutic potential of exogenous stem cells and endogenous NSPCs and highlight innovative technological approaches for designing, developing, and delivering epigenetic therapies for targeted reprogramming of endogenous pools of NSPCs, neural cells at risk, and dysfunctional neural networks to rescue and restore neurologic function in the ischemic brain. PMID: 21403016 [PubMed - in process]         Beike Biotechnology Upgrades Its Processing and Cryopreservation Technology to ... March 16, 2011 at 9:43 AM   Beike Chairman Dr. Hu Xiang commented, "Beike already is one of the leading providers of adult stem cell therapies in the world today, but if we are to remain on the cutting edge of regenerative medicine, we must always look for ways to innovate and ... See all stories on this topic »         2 RI medical textile companies merge March 16, 2011 at 7:10 AM   John Gray, president and CEO of Biomedical Structures, said the merger will give Biomedical more space and allow it to expand into orthopedics and regenerative medicine. The new company hopes to increase its work force to 100 within five years. See all stories on this topic »         Future Tense: Bioprinting March 16, 2011 at 5:34 AM   Researchers: Scientists at the Wake Forest Institute for Regenerative Medicine in Winston-Salem, NC, are heading up the project, which is part of the Armed Forces Institute for Regenerative Medicine. How it works: Bioprinting adapts various printing ... See all stories on this topic »         Regenerative medicine has gone to the dogs March 16, 2011 at 2:27 AM   The 11-year-old Rottweiler-Labrador mix was hit by a car before his first birthday. A surgeon repaired his broken right hind leg using a pin that was too long. As a result of the injury and surgery, Max developed osteoarthritis in his ankle and knee, ... See all stories on this topic »         BMS buys Concordia; will increase engineering capabilities March 16, 2011 at 1:33 AM   Also based in Rhode Island, Concordia Medical provides medical implant technology utilizing biomaterials for tissue engineering and regenerative medicine. Biomedical Structures specializes in the advanced design and manufacturing of medical textiles ... See all stories on this topic »             This email was sent to agupta1213+termsc@gmail.com. Delivered by Feed My Inbox PO Box 682532 Franklin, TN 37068 Account Login Unsubscribe Here