8/9 TE-RegenMed-StemCell feed

TE-RegenMed-StemCell feed         Neural Tube Defects: Review of Experimental Evidence on Stem Cell Therapy and Newer Treatment Options. August 8, 2010 at 9:23 AM                   Related Articles Neural Tube Defects: Review of Experimental Evidence on Stem Cell Therapy and Newer Treatment Options. Fetal Diagn Ther. 2010 Jul 31; Authors: Dhaulakhandi DB, Rohilla S, Rattan KN The failure of closure of the neural tube during development leads to malformations called neural tube defects (NTDs). The most common neural malformations in humans include anencephaly, encephalocele, exencephaly, craniorachischisis spina bifida with or without myelomeningocele, lipomyeloschisis, lipomyelomeningocele, meningocele and myelocystocele. Current preventive strategies are mainly based on pharmacologic/folic acid supplementation. However, stem cell-based and other combination approaches may emerge as potential treatment options for NTDs. This review provides an account of experimental evidence on stem cell therapy and newer treatment options for NTDs which have become available in recent years. PMID: 20689263 [PubMed - as supplied by publisher]                     Stem Cell Therapy for Ischemic Heart Disease. August 8, 2010 at 9:23 AM                   Related Articles Stem Cell Therapy for Ischemic Heart Disease. Antioxid Redox Signal. 2010 Aug 5; Authors: Jameel MN, Zhang J Stem cell transplantation has emerged as a novel treatment option for ischemic heart disease. Different cell types have been utilized and the recent development of induced pluripotent stem cells has generated tremendous excitement in the regenerative field. Bone marrow derived multipotent progenitor cell transplantation in pre-clinical large animal models of post infarction left ventricular remodeling have demonstrated long term functional and bioenergetic improvement. These beneficial effects are observed despite no significant engraftment of bone marrow cells in the myocardium and even lower differentiation of these cells into cardiomyocytes. It is thought to be related to the paracrine effect of these stem cells which secrete factors which lead to long term gene expression changes in the host myocardium, thereby promoting neovascularization, inhibiting apoptosis and stimulating resident cardiac progenitor cells. Future studies are warranted to examine the changes in the recipient myocardium after stem cell transplantation and to investigate the signaling pathways involved in these effects. PMID: 20687781 [PubMed - as supplied by publisher]                         This email was sent to regenmd@gmail.com. Delivered by Feed My Inbox. 230 Franklin Road Suite 814 Franklin, TN 37064 Account Login Unsubscribe Here