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Please add updates@feedmyinbox.com to your address book to make sure you receive these messages in the future. TE-RegenMed-StemCell feed The viruses within -- and what keeps them there January 13, 2010 at 1:52 PM   MIT research finds 'noisiest' neurons persist in the adult brain January 13, 2010 at 12:51 PM   FDA Gives TCA Cellular Therapy Green Light to Proceed with First ALS Adult Stem Cell Trial Using Patient's Own Stem Cells January 13, 2010 at 12:20 PM   Hepatogenesis of Adipose-Derived Stem Cells on Poly-Lactide-Co-Glycolide Scaffolds: In vitro and In vivo Studies. January 13, 2010 at 6:12 AM Related Articles Hepatogenesis of Adipose-Derived Stem Cells on Poly-Lactide-Co-Glycolide Scaffolds: In vitro and In vivo Studies. Tissue Eng Part C Methods. 2010 Jan 11; Authors: Wang M, Pei H, Zhang L, Guan L, Zhang R, Jia Y, Li B, Yue W, Wang Y, Pei X Human adipose-derived stem cells (hASCs) have been shown to be multipotent and could be induced into various cell types, which make them the ideal cell source for cell therapy or tissue engineering. However, differentiation of ASCs into hepatocytes on three-dimensional scaffold, an important part of tissue engineering, has not been reported. In this study, to investigate the hepatogenesis of ASCs on porous poly-lactide-co-glycolide (PLGA) scaffolds, we loaded hASCs on these scaffolds. The cell-scaffold complex was implanted into the peritoneal cavity of 70% hepatectomized rats with or without 14 days of induction in hepatic inducing medium. Our results indicated that hASCs cultured on the PLGA scaffolds in the hepatic inducing medium proliferated more efficiently and could be induced into cells with hepatocyte-like phenotypic and functional properties. Ex vivo studies showed that induced hASCs on PLGA scaffolds survived and maintained hepatic phenotype and functio! n for at least 14 days after implantation, more over, non-induced hASCs on PLGA scaffolds expressed human albumin 14 days after transplantation. Collectively, these results suggest that porous PLGA scaffolds are suitable for the hepatogenesis of hASCs. These findings might be helpful in the application of hASCs-based tissue engineering for liver disease therapy. PMID: 20064016 [PubMed - as supplied by publisher]   Hepatogenesis of Adipose-Derived Stem Cells on Poly-Lactide-Co-Glycolide Scaffolds: In vitro and In vivo Studies. January 13, 2010 at 6:01 AM Related Articles Hepatogenesis of Adipose-Derived Stem Cells on Poly-Lactide-Co-Glycolide Scaffolds: In vitro and In vivo Studies. Tissue Eng Part C Methods. 2010 Jan 11; Authors: Wang M, Pei H, Zhang L, Guan L, Zhang R, Jia Y, Li B, Yue W, Wang Y, Pei X Human adipose-derived stem cells (hASCs) have been shown to be multipotent and could be induced into various cell types, which make them the ideal cell source for cell therapy or tissue engineering. However, differentiation of ASCs into hepatocytes on three-dimensional scaffold, an important part of tissue engineering, has not been reported. In this study, to investigate the hepatogenesis of ASCs on porous poly-lactide-co-glycolide (PLGA) scaffolds, we loaded hASCs on these scaffolds. The cell-scaffold complex was implanted into the peritoneal cavity of 70% hepatectomized rats with or without 14 days of induction in hepatic inducing medium. Our results indicated that hASCs cultured on the PLGA scaffolds in the hepatic inducing medium proliferated more efficiently and could be induced into cells with hepatocyte-like phenotypic and functional properties. Ex vivo studies showed that induced hASCs on PLGA scaffolds survived and maintained hepatic phenotype and functio! n for at least 14 days after implantation, more over, non-induced hASCs on PLGA scaffolds expressed human albumin 14 days after transplantation. Collectively, these results suggest that porous PLGA scaffolds are suitable for the hepatogenesis of hASCs. These findings might be helpful in the application of hASCs-based tissue engineering for liver disease therapy. PMID: 20064016 [PubMed - as supplied by publisher]   The Automation Partnership Premiers Live Cell Observation and Analysis System January 13, 2010 at 5:19 AM   This email was sent to regenmd@gmail.com.  Manage Your Account Don't want to receive this feed any longer? Unsubscribe here.