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NFIX--one gene, two knockouts, multiple effects.
March 31, 2010 at 8:17 AM

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NFIX--one gene, two knockouts, multiple effects.

J Biol. 2008;7(8):29

Authors: Pekarik V, Belmonte JC

A previous knockout of the transcription factor gene nuclear fac! tor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.

PMID: 18983696 [PubMed - indexed for MEDLINE]

 

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