9/10 TE-RegenMed-StemCell feed

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TE-RegenMed-StemCell feed CIRM Nearing Agreement on Underwriters for $500 Million Biotech Loan Program September 9, 2009 at 6:34 pm The board of the California stem cell agency will hold a special, teleconference meeting next Tuesday to consider hiring a bank or two to run its new and ambitious $500 million biotech lending program.Also on the agenda are revised IP rules dealing with affordable access to taxpayer-financed stem cell therapies, although there appears to be no controversy about the rules at this point.CIRM had ThermoGenesis Reports Fourth Quarter and Fiscal 2009 Results September 9, 2009 at 6:22 pm NIAID launches 2009 H1N1 influenza vaccine trial in pregnant women September 9, 2009 at 6:22 pm Tips from the Journals of the American Society for Microbiology September 9, 2009 at 5:22 pm Correction September 9, 2009 at 3:46 pm Based on incorrect information on the CIRM Web site, we stated in the "CIRM President to Gain More Clout" item that Stuart Orkin was chairman of the stem cell agency's Grants Working Group. Orkin says he resigned as chairman last November and is no longer on the panel. According to CIRM, Rainer Storb of the Fred Hutchinson Cancer Research Center served as acting chair at the last meeting of the Sharing the results of research critical to advancement of biological sciences September 9, 2009 at 2:22 pm New type of adult stem cells found in the prostate may be involved in prostate cancer development September 9, 2009 at 2:22 pm Science and media disconnect? Maybe not, says a new study September 9, 2009 at 1:21 pm Cleveland BioLabs and Zhejiang Hisun Pharmaceutical Enter License Agreement for Protectan CBLB612 Hematopoietic Stem Cell Stimulator and Mobilizer in China September 9, 2009 at 10:21 am Pluristem Therapeutics Will Present Its Unique Placenta Derived Stem Cell Therapy Approach at Charles River Biotech Symposium September 9, 2009 at 9:21 am Up-regulation in the expression of renin gene by the influence of aluminium. September 9, 2009 at 6:25 am Up-regulation in the expression of renin gene by the influence of aluminium. J Inorg Biochem. 2009 Aug 14; Authors: Ezomo OF, Matsushima F, Meshitsuka S The excretion of aluminium in urine was significantly increased after intake of analgesics containing aluminium, confirming increased absorption and hence exposure to aluminium with such medication. The effect of aluminium on the kidney was further investigated by study of gene expression in mice. After a single dose of aluminium, an up-regulation of renin gene was found by DNA sequencing of the products of differential display analysis. The up-regulation of renin was confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting experiments in the dose dependent treatments and the time course observation after aluminium citrate injection. The up-regulation of the renin expression by aluminium is a strong indication of the influence of aluminium on the renin-angiotensin-aldosterone-system, resulting in possible induction of essential hypertension. PMID: 19735944 [PubMed - as supplied by publisher] Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34(+) cells via EpoR-mediated JAK(2)/STAT(5) signaling pathway. September 9, 2009 at 6:09 am Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34(+) cells via EpoR-mediated JAK(2)/STAT(5) signaling pathway. J Ethnopharmacol. 2009 Sep 4; Authors: Chen D, Zuo G, Li C, Hu X, Guan T, Jiang R, Li J, Lin X, Li F, Luo C, Wang H, Lei C, Long X, Wang Y, Wang J ETHNOPHARMACOLOGICAL RELEVANCE: Total saponins of Panax ginseng (TSPG), main constituents extracted from Panax ginseng, a highly valued traditional Chinese medicine, have been shown to be an effective agent on hematopoiesis. OBJECTIVE: To investigate the effect and mechanism underlying which TSPG promote human CD34(+) hematopoietic stem and progenitor cells to differentiate into erythroid lineage cells. MATERIALS AND METHODS: The effect of TSPG on erythroid differentiation of purified CD34(+) cells derived from umbilical cord blood (UCB) was determined by methylcellulose assay system and colorimetry for hemoglobin content. The changes of EpoR expression in umbilical cord blood mononuclear cells (UCB-MNCs) and purified CD34(+) cells were detected with Western blotting and flow cytometry, respectively, and observed under Laser Scanning Confocal Microscope (LSCM). RT-PCR was performed to examine EpoR mRNA expression in CD34(+) cells. The effects of TSPG-pretreatment on Epo-induced JAK(2) and STAT(5) tyrosine phosphorylation were analyzed by immunoprecipitation. RESULTS: The addition of TSPG (20-70mg/L) increased the colony formation rate of BFU-E. TSPG (50mg/L) alone used significantly increased the hemoglobin content, the addition of AG490 evidently reduced TSPG-induced elevation of hemoglobin content. TSPG increased expression of EpoR on the surface membrane of CD34(+) cells but did not change the expression of EpoR in total UCB-MNCs. TSPG also increased expression of EpoR mRNA in CD34(+) cells. TSPG markedly enhanced Epo-induced tyrosine phosphorylation of JAK(2) and STAT(5) in UCB-MNCs. CONCLUSION: These findings suggest that TSPG may enhance the erythroid differentiation of hematopoietic stem and progenitor cells via Epo/EpoR-mediated JAK(2) / STAT(5) signaling pathway. PMID: 19735711 [PubMed - as supplied by publisher]   This email was sent to regenmd@gmail.com.  Manage Your Account Don't want to receive this feed any longer? Unsubscribe here.